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Consider the following statements regarding depletion of the ozone layer: 
1) Excessive release of chlorine and bromine in the environment from man-made compounds, such as chlorofluorocarbons. 
2) Occurrence of certain natural phenomena such as sunspots, and stratospheric winds. 
3) Degradation of materials by ultra-violet radiation. 
4) Major volcanic eruptions. 
Which of the above can be categorized as causing ozone depletion?

[ESE 2018 Prelims Paper I]
A
B
C
D